東北大学病院 腫瘍内科｜東北大学大学院医学系研究科・医学部

研究室紹介

研究業績

英文論文 1995-1999年

  1. Yoshioka, T., Gamoh, M., Shineha, R., Ishibashi, S., Shibata, H., Suzuki, T., Murakawa, Y., Kato, S., Shimodaira, H., Ishioka, C., and Kanamaru, R. A new combination chemotherapy with cis-diammine-glycolatoplatinum (Nedaplatin) and 5-fluorouracil for advanced esophageal cancers. Internal Med., 38: 844-848, 1999.
  2. Yoshioka, T., Fukuda, H., Fujiwara, T., Iwata, R., Ido, T., Murakawa, Y., Gamo, M., Ishioka, C., and Kanamaru, R. FDG PET evaluation of residual masses and regrowth of abdominal lymph node metastases from colon cancer compared with CT during chemotherapy. Clin. Nucl. Med., 24: 261-263, 1999.
  3. Yamashita, Y., Sagawa, T., Fujimoto, T., Sugawara, T., Yamada, H., Hoshi, N., Sakuragi, N., Ishioka, C., and Fujimoto, S. BRCA1 mutation tesing for Japanese patients with ovarian cancer in breast cancer screening. Breast Cancer Res. Treat., 58: 11-17, 1999.
  4. Tashiro, M., Kubota, K., Itoh, M., Yoshioka, T., Yoshida, M., Nakagawa, Y., Bereczki, D., and Sasaki, H. Hypometabolism in the limbic system of cancer patients observed by positron emission tomography. Psychooncology, 8: 283-286, 1999.
  5. Sunahara, M., Shishikura, T., Takahashi, M., Todo, S., Yamamoto, N., Kimura, H., Kato, S., Ishioka, C., Ikawa, S., Ikawa, Y., and Nakagawara, A. Mutational analysis of p51A/TAp63g, a p53 homolog, in non-small cell lung cancer and breast cancer . Oncogene, 18: 3761-3765, 1999.
  6. Shimada, A., Kato, S., Enjo, K., Osada, M., Ikawa, Y., Kohno, K., Obinata, M., Kanamaru, R., Ikawa, S., and Ishioka, C. The transcriptional activities of p53 and its homologue p51/p63: similarities and differences. Cancer Res., 59: 2781-2786, 1999.
  7. Sato, Y., Iwata, S., Ishioka, C., and Mizutani, S. Leukemic cells possessing 'First Step' heterozygous p53 mutations show residual wt-p53 activity and overexpress the c-myc gene. Dokkyo J. Med. Sci., 26: 359-367, 1999.
  8. Osada, M., Ishioka, C., Ichinohasama, R., Kadowaki, I., Murakawa, Y., Watanabe, M., Kanamaru, R., and Ikawa, S. Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma. Anti-Cancer Drug Des., 14: 107-114, 1999.
  9. Nichols, K. E., Levitz, S., Shannon, K. E., Wahrer, D. C., Bell, D. W., Chang, G., Hegde, S., Neuberg, D., Shafman, T., Tarbell, N. J., Mauch, P., Ishioka, C., Haber, D. A., and Diller, L. Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease. J. Clin. Oncol., 17: 1259-1266, 1999.
  10. Mukouyama, Y., Chiba, N., Mucenski, M. L., Satake, M., Miyajima, A., Hara, T., and Watanabe, T. Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb. Biology, 9: 833-836, 1999.
  11. Kato, S., Shimada, A., Osada, M., Ikawa, S., Obinata, M., Nakagawara, A., Kanamaru, R., and Ishioka, C. Effects of p51/p63 missense mutations on transcriptional activities of p53 downstream gene promoters1. Cancer Res., 59: 5908-5911, 1999.
  12. Imran, M. B., Kubota, K., Yoshioka, S., Yamada, S., Sato, T., Fukuda, H., Yoshioka, T., Kanamaru, R., Fujiwara, T., and Itoh, M. Sclerosing mediastinitis: Findings on Fluorine-18 fluorodeoxyglucose positron emission tomography. Clin. Nucl. Med., 24: 305-308, 1999.
  13. Bell, D. W., Wahrer, D. C. R., Kang, D. H., MacMahon, M. S., FitzGerald, M. G., Ishioka, C., Isselbacher, K. J., Krainer, M., and Haber, D. A. Common nonsense mutations in RAD52. Cancer Res., 59: 3883-3888, 1999.
  14. Yoshioka, T., Oikawa, H., Takahashi, H., and Kanamaru, R. Reexamination of carbon-11-methionine and positron emission tomography (PET) for diagnosis of pancreatic cancer. In: A. Wakui, H. Yamauchi, and K. Ouchi (eds.), Carcinoma of the pancreas and biliary tract recent underlying problems, pp. 195-202. Tohoku Univ Press, 1998.
  15. Tanaka, Y., Fujii, M., Hayashi, K., Chiba, N., Akaishi, T., Shineha, R., Nishihira, T., Satomi, S., Ito, Y., Watanabe, T., and Satake, M. The chimeric protein, PEBP2b/CBFb-SMMHC,　disoraganizes cytoplasmic stress fibers and inhibits transcriptional activation. Oncogene, 17: 699-708, 1998.
  16. Suzuki, T., Ishioka, C., Kato, S., Mitachi, Y., Shimodaira, H., Sakayori, M., Shimada, A., Asamura, M., and Kanamaru, R. Detection of APC mutations by a yeast-based protein truncation test (YPTT). Genes Chromosomes Cancer, 21: 290-297, 1998.
  17. Shimodaira, H., Filosi, N., Shibata, H., Suzuki, T., Radice, P., Kanamaru, R., Friend, S. H., Kolodner, R. D., and Ishioka, C. Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae. Nature Genet., 19: 384-389, 1998.
  18. Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M., and Ikawa, S. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nature Med., 4: 839-843, 1998.
  19. Ono, S., Yoshioka, T., and Fukuda, H. Diagnostic imaging of pancreatic cancer: special focus on CT, MRI and PET. In: A. Wakui, H. Yamauchi, and K. Ouchi (eds.), Carcinoma of the pancreas and biliary tract, recent underlying problems, pp. 29-43. Tohoku Univ press, 1998.
  20. Okada, H., Watanabe, T., Niki, M., Takano, H., Chiba, N., Yanai, N., Tani, K., Hibino, H., Asano, S., Mucenski, M., Ito, Y., Noda, T., and Satake, M. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene, 17: 2287-2293, 1998.
  21. Ohtsu, A., Boku, N., Tamura, F., Muro, K., Shimada, Y., Saigenji, K., Akazawa, S., Kitajima, M., Kanamaru, R., and Taguchi, T. An early phase II study of a 3-hour infusion of paclitaxel for advanced gastric cancer. Am. J. Clin. Oncol., 21: 416-419, 1998.
  22. Murakawa, Y., Yokoyama, A., Murata, K., Yoshioka, T., and Kanamaru, R. A case of multiple myeloma terminating in acute promyelocytic leukemia. Ann. Cancer Res. Ther., 6: 81-84, 1998.
  23. Murakawa, Y., Yokoyama, A., Kato, S., Yoshioka, T., Ichinohasama, R., Kumabe, T., Yoshimoto, T., Ishioka, C., and Kanamaru, R. Astrocytoma and B-cell lymphoma development in a man with a p53 germline mutation. Jpn. J. Clin. Oncol., 28: 631-637, 1998.
  24. Kusuda, K., Kobayashi, T., Ikeda, S., Ohnishi, M., Chida, N., Yanagawa, Y., Shineha, R., Nishihira, T., Satomi, S., Hiraga, A., and Tamura, S. Mutational analysis of the domain structure of mouse protein phosphatase 2Cb. Biochem. J., 332: 243-250, 1998.
  25. Kobayashi, T., Sadaie, M., Ohnishi, M., Wang, H., Ikeda, S., Hanada, M., Yanagawa, Y., Nakajima, T., and Tamura, S. Isoform-specific phosphorylation of fission yeast type 2C protein phosphatase. Biochem. Biophys. Res. Commun., 251: 296-300, 1998.
  26. Kobayashi, T., Kusuda, K., Ohnishi, M., Wang, H., Ikeda, S., Hanada, M., Yanagawa, Y., and Tamura, S. Isoform specific phosphorylation of protein phosphatase 2C expressed in COS7 cells. FEBS Lett., 430: 222-226, 1998.
  27. Kikuchi, H., Ujiie, S., and Kanamaru, R. The TdT-mediated dUTP nick end labeling assay precisely assesses the DNA damage in human tumor xenografts. Jpn. J. Cancer Res., 89: 862-869, 1998.
  28. Kikuchi, H., Ujiie, S., and Kanamaru, R. Advanced pancreatic cancer successfully treated with continuous infusion of 5-fluorouracil and low-dose cisplatin. Internal Med., 37: 635-637, 1998.
  29. Kato, S. and Kikuchi, A. DNA topoisomerase: The key enzyme that regulates DNA super structure. Nagoya J. Med. Sci., 61: 11-26, 1998.
  30. Hanada, M., Kobayashi, T., Ohnishi, M., Ikeda, S., Wang, H., Katsura, K., Yanagawa, Y., Hiraga, A., Kanamaru, R., and Tamura, S. Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells. FEBS Lett., 437: 172-176, 1998.
  31. Gamo, M. and Kanamaru, R. Systemic therapy for patients with pancreatic cancer. In: A. Wakui, H. Yamauchi, and K. Ouchi (eds.), Carcinoma of the Pancreas and Biliary Tract, pp. 45-59. Sendai: Tohoku University Press, 1998.
  32. FitzGerald, M. G., Marsh, D. J., Wahrer, D., Bell, D., Caron, S., Shannon, K. E., Ishioka, C., Isselbacher, K. J., Garber, J. E., Eng, C., and Haber, D. A. Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer. Oncogene, 17: 727-731, 1998.
  33. Yoshioka, T., Takahashi, H., Oikawa, H., Maeda, S., Ido, T., Akizawa, T., Fukuda, H., and Kanamaru, R. Influence of chemotherapy on FDG uptake by human cancer xenografts in nude mice. J. Nucl. Med., 38: 714-717, 1997.
  34. Yoshioka, T., Fukuda, H., Akaizawa, T., and Kanamaru, R. FDG uptake by human cancer xenografts in nude mice after chemotherapy. CYRIC Annual Report 1996: 128-131, 1997.
  35. Tanaka, Y., Watanabe, T., Chiba, N., Niki, M., Kuroiwa, Y., Nishihira, T., Satomi, S., Ito, Y., and Satake, M. The protooncogene product, PEBP2b/CBFb, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. Oncogene, 15: 677-683, 1997.
  36. Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K., Kanamaru, R., Kanegae, Y., Saito, I., Nakamura, Y., Shiba, K., and Noda, T. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science, 278: 120-123, 1997.
  37. Mihara, K., Miyazaki, M., Kondo, T., Fushimi, K., Tsuji, T., Inoue, Y., Fukaya, K., Ishioka, C., and Namba, M. Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory. Acta Med. Okayama, 51: 261-265, 1997.
  38. Krainer, M., Arrieta, S. S., FitzGerald, M. G., Shimada, A., Ishioka, C., Kanamaru, R., MacDonald, D. J., Unsal, H., Finkelstein, D. M., Bowcock, A., Isselbacher, K. J., and Haber, D. A. Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer. N. Engl. J. Med., 336: 1416-1421, 1997.
  39. Kikuchi, H., Ujiie, S., Wakui, A., Yokoyama, A., and Kanamaru, R. Features of DNA oligonucleosomal fragmentation in human tumor cell lines and its detection by flow cytometry：Utility and limitations. Jpn. J. Cancer Res., 88: 56-63, 1997.
  40. Kambe, M., Ioritani, N., and Kanamaru, R. Enhancement of chemotherapeutic effects with focused shock waves: Extracorporeal shock wave chemotherapy(ESWC). Hum. Cell, 10: 87-94, 1997.
  41. Kambe, M., Arita, D., Kikuchi, H., Funato, T., Tezuka, F., Gamo, M., Murakawa, Y., and Kanamaru, R. Enhancement of the efficacy of anticancer drugs with electroporation: Successful electrochemotherapy against gastric cancer cell lines in vivo and in vitro. Int. J. Clin. Oncol., 2: 111-117, 1997.
  42. Jia, L.-Q., Osada, M., Ishioka, C., Gamo, M., Ikawa, S., Suzuki, T., Shimodaira, H., Niitani, T., Kudo, T., Akiyama, M., Kimura, N., Matsuo, M., Mizusawa, H., Tanaka, N., Koyama, H., Namba, M., Kanamaru, R., and Kuroki, T. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog., 19: 243-253, 1997.
  43. Ishioka, C., Suzuki, T., FitzGerald, M., Krainer, M., Shimodaira, H., Shimada, A., Nomizu, T., Isselbacher, K. J., Haber, D., and Kanamaru, R. Detection of heterozygous truncating mutations in the BRCA1 and APC genes by using a rapid screening assay in yeast. Proc. Natl. Acad. Sci. USA, 94: 2449-2453, 1997.
  44. Ishioka, C., Shimodaira, H., Englert, C., Shimada, A., Osada, M., L-Q., J., Suzuki, T., Gamo, M., and Kanamaru, R. Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells. Biochem. Biophys. Res. Commun., 232: 54-60, 1997.
  45. Hossain, M. D., Hayashi, Y., Nakamura, T., Yoshioka, T., Fujiware, T., Watabe, H., Miyake, M., Takahashi, H., Kanamaru, R., and Itoh, M. Performance study of a miniature gamma ray scintillation vivo probe for tumor localization. Ann Nucl. Med., 11: 173-181, 1997.
  46. Goi, K., Takagi, M., Iwata, S., Delia, D., Asada, M., Rosangela, D., Tsunematsu, Y., Nakazawa, S., Yamamoto, H., Yokota, J., Tamura, K., Saeki, Y., Utsunomiya, J., Takahashi, T., Ueda, R., Ishioka, C., Eguchi, M., Kamata, N., and Mizutani, S. DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation. Cancer Res., 57: 1895-1902, 1997.
  47. Delia, D., Goi, K., Mizutani, S., Yamada, T., Aiello, A., Fontanella, E., Lamorte, G., Iwata, S., Ishioka, C., Stanislaw, K., Reed., J. C., and Pierotti, M. Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations. Oncogene, 14: 2137-2147, 1997.
  48. Chiba, N., Watanabe, T., Nomura, S., Tanaka, Y., Minowa, M., Niki, M., Kanamaru, R., and Satake, M. Differentiation dependent expression and distinct subcellular localization of the protooncogene product,　　PEBP2b/CBFb, in muscle development. Oncogene, 14: 2543-2552, 1997.
  49. Arita, D., Kambe, M., Ishioka, C., and Kanamaru, R. Induction of p53-independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines. Jpn. J. Cancer Res., 88: 39-43, 1997.
  50. Adachi, N., Miyaike, M., Kato, S., Kanamaru, R., Koyama, H., and KIkuchi, A. Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain. Nucl. Acid Res., 25: 3135-3142, 1997.
  51. Sasahara, Y., Kobayashi, T., Onodera, H., Onoda, M., Ohnishi, M., Kato, S., Kusuda, K., Shima, H., Nogao, M., Abe, H., Yanagawa, Y., Hiraga, A., and Tamura, S. Okadaic acid suppresses neural differentiation-dependent expression of the neurofilament-L gene in P19 embryonal carcinoma cells by post-transcriptional modification. J. Biol. Chem., 271: 25950-25957, 1996.
  52. Saijyo, S., Kudo, T., Katayose, Y., Saeki, H., Chiba, N., Suzuki, M., Tominaga, T., and Matsuno, S. A new in vitro model of specific targeting therapy of cancer: Retargeting of PWM-LAK cells with bispecific antibodies greatly enhances cytotoxicity to hepatocellular carcinoma. Tohoku J. Exp. Med., 178: 113-127, 1996.
  53. Ohnishi, M., Nakagawara, K., Mori, M., Kobayashi, T., Kato, S., Sasahara, Y., Kusuda, K., Chida, N., Yanagawa, Y., Hiraga, A., Takeuchi, T., and Tamura, S. Localization of the mouse protein serine/threonine phosphatase 2Cb gene to chromosome 17E4-5. Genomics, 32: 134-136, 1996.
  54. Murata, K., Murakawa, Y., and Kanamaru, R. Mechanism of cytotoxic effects of taxotere in the K562 human premyelocytic leukemia line. Int. J. Clin. Oncol., 1: 80-86, 1996.
  55. Kobayashi, T., Yasui, A., Ohnishi, M., Kato, S., Sasahara, Y., Kusuda, K., Chida, N., Yanagawa, Y., Hiraga, A., and Tamura, S. Enhanced UV sensitivity of yeast cells induced by overexpression of Mg2+ -dependent protein phosphatasea (type2Ca). Mut. Res., 362: 213-217, 1996.
  56. Kato, S., Kobayashi, T., Kusuda, K., Nishina, Y., Nishimune, Y., Yomogida, K., Yamamoto, M., Sakagami, H., Kondo, H., Ohnishi, M., Chida, N., Yanagawa, Y., and Tamura, S. Differentiation-dependent enhanced expression of protein phosphatase 2Cb in germ cells of mouse seminiferous tubules. FEBS Letters, 396: 293-297, 1996.
  57. Kambe, M., Ioritani, N., Shirai, S., Kambe, K., Kuwahara, M., Arita, D., Funato, T., Shimodaira, H., Gamo, M., Orikasa, S., and Kanamaru, R. Enhancement of chemotherapeutic effects with focused shock waves: Extracorporeal shock wave chemotherapy (ESWC). In Vivo, 10: 369-376, 1996.
  58. Kambe, M., Arita, D., Kikuchi, H., Funato, T., Tezuka, F., Gamo, M., Murakawa, Y., and Kanamaru, R. Enhancing the effect of anticancer drugs against the colorectal cancer cell line with electroporation. Tohoku J. Exp. Med., 180: 161-171, 1996.
  59. Iijima, M., Mihara, K., Kondo, T., Tsuji, T., Ishioka, C., and Namba, M. Mutation in p53 and de-regulation of p53-related gene expression in three human cell lines immortalized with 4-nitroquinoline 1-oxide or 60Co gamma rays. Int. J. Cancer, 66: 698-702, 1996.
  60. Hossain, A., Osada, M., Ikawa, S., Watanabe, M., and Kikuchi, H. Characterization of the Ah receptor associated protein, p45. Kareiigaku Kenkyusyo Zassi, 48: 59-65, 1996.
  61. Saijyo, S., Kudo, T., Suzuki, M., Katayose, Y., Shinoda, M., Muto, T., Fukuhara, K., Suzuki, T., and Matsuno, S. Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1. Tohoku J. Exp. Med., 177: 61-71, 1995.
  62. Kato, S., Terasawa, T., Kobayashi, T., Ohnishi, M., Sasahara, Y., Kusuda, K., Yanagawa, Y., Hiraga, A., Matsui, Y., and Tamura, S. Molecular cloning and expression of mouse Mg2+-dependent protein phosphatase b-4(Type 2Cb-4). Arch. Biochem. Biophys., 318: 387-393, 1995.
  63. Ishioka, C., Englert, C., Winge, P., Yan, Y.-X., Engelstein, M., and Friend, S. H. Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene, 10: 1485-1492, 1995.
  64. Ishioka, C., Ballester, R., Engelstein, M., Vidal, M., Kassel, J., The, I., Bernards, A., Gusella, J. F., and Friend, S. H. A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene. Oncogene, 10: 841-847, 1995.