東北大学病院 腫瘍内科｜東北大学大学院医学系研究科・医学部

研究室紹介

研究業績

英文論文 2013年度

  1. Kobayashi, N.，Hong, C.，Klinman, D. M.，Shirota, H. Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2. J Immunol 190: 1882-1889 (2013)
  2. Yoshino, Y.，Akiyama, S.，Ouchi, K.，Oishi, T.，Takahashi, H.，Lee, J.，Takahashi, S.，Shimodaira, H.，Kato, S.，Ishioka, C. Acute exacerbation of paraneoplastic neurological syndrome after massive tumor lysis of neuroendocrine carcinoma by chemoradiotherapy. International Cancer Conference Journal 2: 247-250 (2013)
  3. Shirota, H.，Klinman, D. M. Use of CpG oligonucleotides for cancer immunotherapy and their effect on immunity in the tumor microenvironment. Immunotherapy 5: 787-9 (2013)
  4. Soeda, H.，Shimodaira, H.，Watanabe, M.，Suzuki, T.，Gamoh, M.，Mori, T.，Komine, K.，Iwama, N.，Kato, S.，Ishioka, C. Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer. Int J Clin Oncol 18: 670-7 (2013)
  5. Otsuka, K.，Imai, H.，Soeda, H.，Komine, K.，Ishioka, C.，Shibata, H. Practical utility of circulating tumour cells as biomarkers in cancer chemotherapy for advanced colorectal cancer. Anticancer Res 33: 625-9 (2013)
  6. Takahashi, M.，Kakudo, Y.，Takahashi, S.，Sakamoto, Y.，Kato, S.，Ishioka, C. Overexpression of DRAM enhances p53-dependent apoptosis. Cancer Med 2: 1-10 (2013)
  7. Kawai, S.，Kato, S.，Imai, H.，Okada, Y.，Ishioka, C. Suppression of FUT1 attenuates cell proliferation in the HER2-overexpressing cancer cell line NCI-N87. Oncol Rep 29: 13-20 (2013)
  8. Leroy, B.，Fournier, J. L.，Ishioka, C.，Monti, P.，Inga, A.，Fronza, G.，Soussi, T. The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis. Nucleic Acids Res 41: D962-9 (2013)
  9. Tewary, P.，de la Rosa, G.，Sharma, N.，Rodriguez, L. G.，Tarasov, S. G.，Howard, O. M.，Shirota, H.，Steinhagen, F.，Klinman, D. M.，Yang, D.，Oppenheim, J. J. beta-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-alpha production by human plasmacytoid dendritic cells, and promote inflammation. J Immunol 191: 865-74 (2013)
  10. Toiyama, Y.，Takahashi, M.，Hur, K.，Nagasaka, T.，Tanaka, K.，Inoue, Y.，Kusunoki, M.，Boland, C. R.，Goel, A. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst 105: 849-59 (2013)
  11. Kato, T.，Ohtani, H.，Ueki, H.，Mori, T. Curative resection of gastric tube cancer by hand-assisted thoracoscopic surgery. Esophagus 10: 123-127 (2013)
  12. Towler, W. I.，Zhang, J.，Ransburgh, D. J.，Toland, A. E.，Ishioka, C.，Chiba, N.，Parvin, J. D. Analysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing. Hum Mutat 34: 439-45 (2013)
  13. Hur, K.，Toiyama, Y.，Takahashi, M.，Balaguer, F.，Nagasaka, T.，Koike, J.，Hemmi, H.，Koi, M.，Boland, C. R.，Goel, A. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut 62: 1315-26 (2013)
  14. Shibahara, I.，Sonoda, Y.，Saito, R.，Kanamori, M.，Yamashita, Y.，Kumabe, T.，Watanabe, M.，Suzuki, H.，Watanabe, T.，Ishioka, C.，Tominaga, T. The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence. Neuro Oncol 15: 1151-9 (2013)
  15. Kurahashi, I.，Fujita, Y.，Arao, T.，Kurata, T.，Koh, Y.，Sakai, K.，Matsumoto, K.，Tanioka, M.，Takeda, K.，Takiguchi, Y.，Yamamoto, N.，Tsuya, A.，Matsubara, N.，Mukai, H.，Minami, H.，Chayahara, N.，Yamanaka, Y.，Miwa, K.，Takahashi, S.，Takahashi, S.，Nakagawa, K.，Nishio, K. A microarray-based gene expression analysis to identify diagnostic biomarkers for unknown primary cancer. PLoS One 8: e63249 (2013)
  16. Matsuzawa, A.，Kanno, S.，Nakayama, M.，Mochiduki, H.，Wei, L.，Shimaoka, T.，Furukawa, Y.，Kato, K.，Shibata, S.，Yasui, A.，Ishioka, C.，Chiba, N. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Mol Cell 53: 101-14 (2014)
  17. Hodge, D. L.，Berthet, C.，Coppola, V.，Kastenmuller, W.，Buschman, M. D.，Schaughency, P. M.，Shirota, H.，Scarzello, A. J.，Subleski, J. J.，Anver, M. R.，Ortaldo, J. R.，Lin, F.，Reynolds, D. A.，Sanford, M. E.，Kaldis, P.，Tessarollo, L.，Klinman, D. M.，Young, H. A. IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice. J Autoimmun (2014)
  18. Shirota, H.，Klinman, D. M. TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens. Methods Mol Biol 1139: 337-44 (2014)
  19. Shirota, H.，Klinman, D. M. Recent progress concerning CpG DNA and its use as a vaccine adjuvant. Expert Rev Vaccines 13: 299-312 (2014)